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Neonatal abstinence syndrome case study

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Background: Use or abuse of opioids and related drugs during pregnancy increases the risk of maternal and neonatal morbidities, including increased susceptibility to Neonatal Abstinence Syndrome NAS. Severity of NAS is determined by both environmental and genetic factors, but the level of influence each one of them has in determining the severity of NAS is not fully understood. Since the incidence and severity of NAS vary a lot among susceptible infants, twin studies might give us valuable insights into understanding the relative roles of environmental and genetic factors at the onset of the disease and during its progression. Higher concordance of occurrence and severity of NAS in monozygotic twins compared to dizygotic twins would suggest a genetic role in the pathogenesis of NAS.
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Opioid Use and Opioid Use Disorder in Pregnancy

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Opioid Use and Opioid Use Disorder in Pregnancy | ACOG

Background and aims: The relationship between gestational age at delivery and the severity of neonatal abstinence syndrome NAS is poorly understood. Our objective was to compare the length of pharmacotherapy and hospital stay among opioid-exposed infants born during the late pre-term, early term, full term and late term periods. Design: Retrospective cohort study of infants affected by NAS. Measurements: NAS requiring pharmacotherapy with opioids and hospital stay duration were compared between gestational age cohorts. Interaction by type of maternal medication was evaluated.
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A multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome

Objectives: To compare pharmacologic treatment strategies for neonatal abstinence syndrome NAS with respect to total duration of opioid treatment and length of inpatient hospital stay. Methods: We conducted a cohort analysis of late preterm and term neonates who received inpatient pharmacologic treatment of NAS at one of 20 hospitals throughout 6 Ohio regions from January through July Physicians managed NAS using 1 of 6 regionally based strategies. Results: Among pharmacologically treated infants, we documented infants managed using an established NAS weaning protocol and patients managed without protocol-driven weaning. Regardless of the treatment opioid chosen, when we accounted for hospital variation, infants receiving protocol-based weans experienced a significantly shorter duration of opioid treatment
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Background: Use or abuse of opioids and related drugs during pregnancy increases the risk of maternal and neonatal morbidities, including increased susceptibility to Neonatal Abstinence Syndrome NAS. Severity of NAS is determined by both environmental and genetic factors, but the level of influence each one of them has in determining the severity of NAS is not fully understood. Since the incidence and severity of NAS vary a lot among susceptible infants, twin studies might give us valuable insights into understanding the relative roles of environmental and genetic factors at the onset of the disease and during its progression.
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